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其實我想知邊條link 講 自閉症係父親遺傳only?
Subject: Autism genetics
Category: Health > Medicine
Asked by: freddo99-ga
List Price: $20.00 Posted: 21 Jun 2004 13:01 PDT
Expires: 21 Jul 2004 13:01 PDT
Question ID: 364147
I have been told that recent studies concluded that the gene
responsible for autism is transmitted by the father and not by the
mother. Is this true? Does this mean than children of a woman whose
brother is autistic are not at risk?
If the answer to the first question is no, do we have an idea about
the probability that the children of the sister of an autistic man
develop autism?
answer:
Hi Freddo99,
You question is complicated by the fact that there is no one gene for
autism - there are, in fact, at least seven. Four of these are linked
to genes found on the autosomal chromosomes 3, 7, 13, and 15; the
other three are linked to the X chromosome (making them sex-linked to
the mother). The article linked by Scriptor (in the comments) also
suggests a link to a gene on chromosome 2. All this is to say that
the genetic basis for autism is really complicated, and that (given
the X-linkage), there is support for it being passed through the
mother's line. It's probably impossible to say what the probability
that the nieces/nephews of an autistic man would be - but since autism
"appears to be the most highly genetic of all psychiatric disorders"
(again, from Scriptor's article) there's probably an elevated risk
over the general population.
Remember, too, that with all the different genes that can contribute
to autism, this disease has a wide range of severity. Often you'll
see the genetics referred to as "autism predisposition" since having
the gene may make it more likely for a child to be autistic, but
doesn't guarantee that.
I know this isn't as clear an answer as you might have wanted. I'm
including several websites on the genetics of autism that I think
you'll find interesting.
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發表於 13-4-26 13:57
